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HomeChemistrySteel/catalyst-free sequential C–N bond forming cascades at room temperature: environment-friendly one-pot synthesis...

Steel/catalyst-free sequential C–N bond forming cascades at room temperature: environment-friendly one-pot synthesis of 5-aminoimidazoles from aryl glyoxals, anilines, and amidines


An expeditious one-pot methodology for the synthesis of extremely substituted 5-aminoimidazoles from glyoxals, anilines, and amidines was evaluated underneath metallic/catalyst-free circumstances operative at room temperature. The current protocol constitutes an environmentally pleasant strategy for the synthesis of extremely substituted 5-aminoimidazoles, that are necessary constructing blocks of a number of bioactive and medicinal compounds. The readily and commercially accessible beginning supplies will be shortly assembled into imidazoles utilizing this protocol and scaling up this course of doesn’t require chromatographic purification. Moreover, the response of 5-aminoimidazole with 2-bromobenzoyl chloride can present a novel imidazo[5,1-b]quinazolin-9(4H)-one, thus showcasing the applicability of this protocol.

Graphical abstract: Metal/catalyst-free sequential C–N bond forming cascades at room temperature: environment-friendly one-pot synthesis of 5-aminoimidazoles from aryl glyoxals, anilines, and amidines

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