A mutation generally known as APOE3 Christchurch seems to have protected the lady.
Because of a uncommon genetic mutation, Aliria Rosa Piedrahita de Villegas ought to have had Alzheimer’s disease in her 40s and passed away from it in her 60s.
Her brain is now providing important information on the pathology of dementia and potential treatments for Alzheimer’s disease since she lived dementia-free into her 70s.
The lady, from Medellin, Colombia, was a member of an extended family with a mutation in the PSEN1 gene, as researchers at Massachusetts General Hospital (MGH) and other institutions initially reported in 2019.
Because the PSEN1 E280A mutation is autosomal dominant, only one copy of the gene is necessary to cause disease.
This woman did not start displaying symptoms of Alzheimer’s until she was in her early 70s when carriers of the mutation normally display signs of the disease in their 40s or 50s and pass away from it shortly after. She passed away at the age of 77 in 2020 from metastatic melanoma.
“This is a ground-breaking case for Alzheimer’s disease and has already opened new paths for treatment and prevention, which we’re currently pursuing with some collaborators. This work is now bringing light into some of the mechanisms of resistance to Alzheimer’s disease” says investigator Yakeel T. Quiroz, Ph.D.
Quiroz is director of the Multicultural Alzheimer Prevention Program (MAPP) at Mass General, an Associate Professor of Psychology in the Department of Psychiatry at Harvard Medical School, and Paul B. and Sandra M. Edgerley MGH Research Scholar 2020-2025.
The key difference in the Colombian woman’s ability to fend off the disease for three decades appeared to be that in addition to having the PSEN1 E280A mutation, she was also a carrier of both copies of a mutation known as APOE3 Christchurch.
The APOE family of genes controls the production of apolipoproteins, which transport lipids (fats) in blood and other bodily fluids.
The APOE2 variant is known to be protective against Alzheimer’s dementia, while the APOE4 variant is linked to an increased risk for the disease.
APOE3, the most common variant, is not typically associated with either reduced or increased risk for Alzheimer’s.
As Quiroz and colleagues now report in the neuropathology journal Acta Neuropathologica, the woman did, in fact, have pathologic features of Alzheimer’s disease in her brain, but not in regions of the brain where the hallmarks of Alzheimer’s are typically found.
“This patient gave us a window into many competing forces — abnormal protein accumulation, inflammation, lipid metabolism, homeostatic mechanisms — that either promote or protect against disease progression, and begin to explain why some brain regions were spared while others were not,” says Justin Sanchez, AB, co-first author, and an investigator at MGH Neurology.
Researchers identified in Aliria’s brain a distinct pattern of abnormal aggregation or “clumping” of tau, a protein known to be altered in Alzheimer’s disease and other neurologic disorders.
In this case, the tau pathology largely spared the frontal cortex, which is important for judgment and other “executive” functions, and the hippocampus, which is important for memory and learning.
Instead, the tau pathology involved the occipital cortex, the area of the brain at the back of the head that controls visual perception.
The occipital cortex was the only major brain region to exhibit typical Alzheimer’s features, such as chronic inflammation of protective brain cells called microglia, and reduced levels of APOE expression.
“Thus, the Christchurch variant may impact the distribution of tau pathology, modulates age at onset, severity, progression, and clinical presentation of [autosomal dominant Alzheimer’s disease], suggesting doable therapeutic methods,” the researchers write.
“It’s seldom that we’ve got good surprises whereas learning familial Alzheimer’s illness brains. This case confirmed an amazingly clear protected phenotype. I’m positive our molecular and pathologic findings will at the least recommend some avenues of analysis, and elicit hope for a profitable therapy in opposition to this dysfunction.”- says co-first creator, Diego Sepulveda-Falla, MD, Analysis Lead at College Medical Middle Hamburg-Eppendorf in Hamburg, Germany.
“This distinctive case is an experiment designed by nature that teaches us a option to stop Alzheimer’s: let’s observe, be taught and imitate nature,” concludes Francisco Lopera, MD, director of the Neuroscience Group of Antioquia in Medellín, Colombia. Lopera is a co-senior creator and the neurologist who found this household and has been following them for the final 30 years.
Reference: “Distinct tau neuropathology and mobile profiles of an APOE3 Christchurch homozygote protected in opposition to autosomal dominant Alzheimer’s dementia” by Diego Sepulveda-Falla, Justin S. Sanchez, Maria Camila Almeida, Daniela Boassa, Juliana Acosta-Uribe, Clara Vila-Castelar, Liliana Ramirez-Gomez, Ana Baena, David Aguillon, Nelson David Villalba-Moreno, Jessica Lisa Littau, Andres Villegas, Thomas G. Seaside, Charles L. White III, Mark Ellisman, Susanne Krasemann, Markus Glatzel, Keith A. Johnson, Reisa A. Sperling, Eric M. Reiman, Joseph F. Arboleda-Velasquez, Kenneth S. Kosik, Francisco Lopera and Yakeel T. Quiroz, 15 July 2022, Acta Neuropathologica.
The research was funded by the Nationwide Institutes of Well being, MGH Government Committee on Analysis (MGH Analysis Scholar Award), Alzheimer’s Affiliation, the Deutsche Forschungsgemeinschaft, Universidad de Antioquia, the Werner Otto Stiftung, and the German Federal Ministry of Schooling and Analysis.