Catalytic switch hydrogenolysis (CTH) has emerged as a sustainable and carbon-neutral biorefinery because of the lower within the carbon footprint and the excessive atom and vitality effectivity. Herein, heteropoly acids (HPAs) because the inexperienced catalysts had been used for the CTH of Kraft lignin (KL) into lignin oil underneath gentle circumstances. It’s discovered that the forms of HPAs, H-donor solvent and response temperature affected considerably the conversion of Kraft lignin. The conversion of 95.0% and 83.8% had been achieved in isopropanol at 190 °C for five h over SiW12 and PW12, respectively. Nonetheless, the degradation of eucalyptus Kraft lignin (EKL) offered phenolic monomers with the very best yield of 42.6% utilizing SiW12. Molecular dynamics (MD) simulation confirmed that SiW12 and PW12 in isopropanol usually tend to be near lignin in contrast in n-propanol. The relative common molecular weight of obtained lignin oil ranges from 100 Da to 700 Da, together with phenolic monomers, dimers and trimers. The lignin monomer merchandise are primarily composed of guaiacols and syringols with 0 to three carbon aspect chains. The simultaneous depolymerization and deoxygenation of KL throughout CTH brought about the high-boiling natural fraction, analyzed by Fourier transform-ion cyclotron resonance mass spectrometer (FT-ICR MS) geared up with an electrospray damaging ion supply (ESI-), maintained extremely fragrant constructions and have decrease O/C and better H/C ratios in comparison with preliminary lignin. This work displays a potential utility of the CTH for the conversion of technical lignin to chemical substances and biofuels.