Thursday, October 6, 2022
HomeChemistryDesign of a inexperienced chemoenzymatic cascade for scalable synthesis of bio-based styrene...

Design of a inexperienced chemoenzymatic cascade for scalable synthesis of bio-based styrene options


As renewable lignin constructing blocks, hydroxystyrenes are significantly interesting as both a substitute or addition to styrene-based polymer chemistry. These monomers are obtained by decarboxylation of phenolic acids and sometimes subjected to chemical modifications of their phenolic hydroxy teams to enhance polymerization behaviour. Regardless of efforts, a easy, scalable, and purely (chemo)catalytic synthesis of acetylated hydroxystyrenes stays elusive. We thus suggest a custom-made chemoenzymatic route that makes use of a phenolic acid decarboxylase (PAD). Our course of growth technique encompasses a computational solvent evaluation informing about solubilities and viable reactor operation modes, experimental solvent screening, cascade engineering, heterogenization of biocatalyst, tailoring of acetylation circumstances, and response upscale in a rotating mattress reactor. By this implies, we established a clear one-pot two-step course of that makes use of the renewable solvent CPME, bio-based phenolic acid educts and reusable immobilised PAD. The general chemoenzymatic response cascade was demonstrated on a 1 L scale to yield 18.3 g 4-acetoxy-3-methoxystyrene in 96% remoted yield.

Graphical abstract: Design of a green chemoenzymatic cascade for scalable synthesis of bio-based styrene alternatives

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