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An environmentally accountable path to tezacaftor, a drug for therapy of cystic fibrosis ready in water through ppm Au catalysis as entry to 2-substituted indoles


Inexperienced Chem., 2022, 24,6517-6523
DOI: 10.1039/D2GC01828D, Paper
Nico Fleck, Rohan M. Thomas, Marcel Müller, Stefan Grimme, Bruce H. Lipshutz
An environmentally accountable synthesis of tezacaftor, a drug accepted in 2018 presently in use for therapy of cystic fibrosis, is described using chemistry in water enabled by the nonionic surfactant TPGS-750-M.
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