With a purpose to make recycling a viable technique for post-consumer plastics, economically possible revalorization processes have to be developed. The ammonolysis of polyamides will be such a cutting-edge recycling expertise; nevertheless, as a result of inflexible construction of those polyamide plastics, working situations of present ammonolysis processes are harsh, together with excessive temperatures (>300 °C) and excessive NH3 pressures. Right here, we report a really inexperienced and stylish ammonolysis means of the broadly considerable polyamide 66 by utilizing a tough Lewis acid catalyst and 1 bar of NH3 in a easy glycol solvent at 200 °C. Computational research revealed that particularly the vicinal diol moiety of those glycol solvents performs a key function in activation of the ammonia nucleophile, with glycerol being the simplest solvent, reaching the depolymerization equilibrium after 20 h even and not using a catalyst. To our delight, a biosourced glycerol (obtained from the saponification of triglycerides) might additionally instantly function an acceptable solvent, even outperforming the ammonolysis course of in extremely purified glycerol.